Rotavirus vaccine intestinal side effect company tried to public domain and give away cell line but countries
In 1998, a rotavirus vaccine (RotaShield, by Wyeth) was licensed for use in the United States. Clinical trials in the United States, Finland, and Venezuela had found it to be 80 to 100% effective at preventing severe diarrhea caused by rotavirus A, and researchers had detected no statistically significant serious adverse effects. The manufacturer of the vaccine, however, withdrew it from the market in 1999, after it was discovered that the vaccine may have contributed to an increased risk for intussusception, or bowel obstruction, in one of every 12,000 vaccinated infants.[27] There then followed eight years of delay until rival manufacturers were able to introduce new vaccines that were shown to be more safe and effective in children:
Cool article in skeptical inquirer
Magazine might be a good format for pseudoscience rhet defense
Measured in litres (L) or cubic metres, is an inverse measure of the ‘stiffness’ of the suspension with the driver mounted in free air. It represents the volume of air that has the same stiffness as the driver’s suspension when acted on by a piston of the same area (S d) as the cone.
Women’s curling is really interesting! Found it on hotel TV accidentally. The fascinating aspect (and this is probably preserved in men’s curling) is that all the conversations the teammates have regarding their strategy are broadcast; all the players wear hot mics at all times. I don’t recall hearing that in other sports.
The conversation keeps coming back – for example, I recently saw another version of it asking about the limitations rounded rects in JavaScript + WebGL (vs Java + OpenGL). Solutions are invented, but problems don’t necessarily stay solved – they keep needing to be re-solved.
|”and I’m still not sure it holds up in the real world“
Writing literature is a solo endeavour.
Modern programming is more like writing scientific literature, where multiple persons collaborate, and reading and understanding earlier work and maintaining a correct set of links to such works is half the work, if not more.
That, I think, is why literate programming doesn’t quite work. It works for Mathematica notebooks, iPython notebooks and the like, but not for larger works.|
I came across a paper a little while ago, where the core-hole lifetime broadening. I thought this was bollocks.
But it seems as though these sorts of effects are indeed possible?
In 1963 the Jaynes–Cummings model[84] was developed describing the system of a two-level atom interacting with a quantized field mode (i.e. the vacuum) within an optical cavity. It gave nonintuitive predictions such as that an atom’s spontaneous emission could be driven by field of effectively constant frequency (Rabi frequency). In the 1970s experiments were being performed to test aspects of quantum optics and showed that the rate of spontaneous emission of an atom could be controlled using reflecting surfaces.[85][86] These results were at first regarded with suspicion in some quarters: it was argued that no modification of a spontaneous emission rate would be possible, after all, how can the emission of a photon be affected by an atom’s environment when the atom can only “see” its environment by emitting a photon in the first place? These experiments gave rise to cavity quantum electrodynamics (CQED), the study of effects of mirrors and cavities on radiative corrections. Spontaneous emission can be suppressed (or “inhibited”)[87][88] or amplified. Amplification was first predicted by Purcell in 1946[89] (the Purcell effect) and has been experimentally verified.[90] This phenomenon can be understood, partly, in terms of the action of the vacuum field on the atom.[91]
The solution to the heat-diffusion equation is a gaussian profile. But
McDonald, A., K. Woodruff, Diego Gonzalez Diaz, and B. Jones. Electron Drift and Longitudinal Diffusion in High Pressure Xenon-Helium Gas Mixtures, 2019.
I love how people used to regularly use solutions as laser-line filters. You see this in some fluorescence measurements, and most recently, the first observation of two-photon excitation:
Starship project is somehow unique, but it seems like the development of the Boeing 747
Time was so short that the 747’s full-scale mock-up was built before the factory roof above it was finished.[40]
During the final months before delivery of the first aircraft, the company had to repeatedly request additional funding to complete the project. Had this been refused, Boeing’s survival would have been threatened.[18][57] The firm’s debt exceeded $2 billion, with the $1.2 billion owed to the banks setting a record for all companies. Allen later said, “It was really too large a project for us.”[58] Ultimately, the gamble succeeded, and Boeing held a monopoly in very large passenger aircraft production for many years.[59]
Project cost $5.8 billion in 2020 dollars
also interesting:
The project was designed with a new methodology called fault tree analysis, which allowed the effects of a failure of a single part to be studied to determine its impact on other systems.[1] To address concerns about safety and flyability, the 747’s design included structural redundancy, redundant hydraulic systems, quadruple main landing gear and dual control surfaces.[29]
Bought Fava beans on a whim at the grocery store. Looking up how to cook them, I found:
As the authors state, “In favism, there are two main actors: the bean and the red cell.” Fava beans and genetic susceptibility must come together to elicit the outcome of favism. Ironically, the fava bean plant (Vicia faba; known to many as the broad bean) may have been the first plant to be domestically cultivated and produces a protein-rich bean that can be eaten hot or cold. The problem is that the bean’s protein content can include as much as 2 percent vicine and convicine, which are converted in the gut to divicine and isouramil. These highly redox proteins are likely to retard rotting of the bean, but produce reactive oxygen species (ROS) including the superoxide anion and hydrogen peroxide, which rapidly oxidize NADPH and glutathione. These molecules are normally detoxified by catalase and glutathione peroxidase, in enzymatic reactions that depend on NADPH. Because NADPH levels are very low in G6PD-deficient red cells, these undergo severe oxidative damage. A characteristic feature of favism is that intracellular and extracellular hemolysis coexist. The intracellular damage is easy to explain, whereas extracellular hemolysis occurs as complement is fixed on the cell and triggers phagocytosis.
The Supreme Court declined to follow the case of Computer Edge Pty. Ltd. v. Apple Computer, Inc.[2] decided by the High Court of Australia, which had virtually identical facts. In that case, the court held that the chips contained a “sequence of electrical impulses” which could not be subject to copyright.
